Noël Kristi Wells (born December 23, 1986), is an American actress, voice actress, comedian, director, musician, and writer. She is known for her role as Rachel on Master of None and as a cast member on Saturday Night Live for the 2013–2014 season.

Noël Wells plays as Kelsey Bern (voice) in Star Trek: Lower Decks.
Noël Wells is the top #1 member of the cast and appears in 139 episodes.

Eugene Cordero is an American actor, writer, and comedian. Frequently appearing in comedic roles, he has been featured as a series regular on the comedies Other Space (2015), Bajillion Dollar Propertie$ (2017–2019), Tacoma FD (2019–present), and Star Trek: Lower Decks (2020–present). His television appearances also include recurring roles on House of Lies (2014), Crazy Ex-Girlfriend (2015–2017), The Good Place (2016–2020), and Wrecked (2018). Outside of comedy, he has been a series regular on the Disney+ superhero series Loki since 2021. Cordero's film roles include the comedy-drama The Kings of Summer (2013), the monster adventure Kong: Skull Island (2017), and the crime drama The Mule (2018).

Eugene Cordero plays as Andy Parrish in Star Trek: Lower Decks.
Eugene Cordero is the top #2 member of the cast and appears in 36 episodes.

Tawny Newsome (born February 24, 1983) is an American musician, comedian and actress.

Tawny Newsome plays as Chelsea Leight-Leigh in Star Trek: Lower Decks.
Tawny Newsome is the top #3 member of the cast and appears in 34 episodes.

Jeremiah O'Connell (born February 17, 1974) is an American actor, director, and television personality. He is known for his roles as Quinn Mallory in the television series Sliders, Andrew Clements in My Secret Identity, Vern Tessio in the film Stand by Me (1986), Joe in Joe's Apartment (1996), Frank Cushman in Jerry Maguire (1996), Derek in Scream 2 (1997), Charlie Carbone in Kangaroo Jack (2003), and Detective Woody Hoyt on the drama Crossing Jordan. He starred in the Canadian science-fiction sitcom My Secret Identity from 1988 to 1991 as the teen hero who develops superhuman traits. During a summer break from NYU, Jerry starred in the feature film Calendar Girl alongside Jason Priestley and Gabriel Olds. He also appeared in the short-lived ABC sitcom Camp Wilder, with Jay Mohr, and Hilary Swank in 1992. O'Connell starred as Detective Woody Hoyt on the NBC crime drama Crossing Jordan (2001-2007). He played Hoyt in several episodes of Las Vegas. He starred as Pete Kaczmarek in the single 2010–2011 season of the CBS dramedy The Defenders, alongside Jim Belushi. He also had a starring role in the comedy horror film Piranha 3D (2010). On May 15, 2013, it was announced that O'Connell would play Stuart Strickland on We Are Men, alongside Tony Shalhoub. He voices Commander Jack Ransom on the animated series Star Trek: Lower Decks. In July 2021, CBS announced that O'Connell would be joining The Talk as a permanent co-host, replacing Sharon Osbourne. He co-hosts, with his wife Rebecca Romijn, the reality dating show The Real Love Boat (2022) and hosts a version of Pictionary (2022) syndicated on FOX .

Jerry O'Connell plays as Harley Carter in Star Trek: Lower Decks.
Jerry O'Connell is the top #4 member of the cast and appears in 20 episodes.

Jack Henry Quaid (born April 24, 1992) is an American actor. The son of actors Dennis Quaid and Meg Ryan, he is best known for playing Marvel in the science fiction film The Hunger Games and for his leading role as a vigilante in the Prime Video superhero series The Boys. Wikipedia

Jack Quaid plays as Hughie Campbell in Star Trek: Lower Decks.
Jack Quaid is the top #5 member of the cast and appears in 16 episodes.

Dawnn Lewis (born August 13, 1961) is an American actress, voice actress, singer and songwriter.

Dawnn Lewis plays as Captain Carol Freeman (voice) in Star Trek: Lower Decks.
Dawnn Lewis is the top #6 member of the cast and appears in 10 episodes.

Gillian Vigman (born January 28, 1972) is an American actress, comedian, and screenwriter.

Gillian Vigman plays as Doctor T’Ana (voice) in Star Trek: Lower Decks.
Gillian Vigman is the top #7 member of the cast and appears in 10 episodes.

Frederick "Fred" Tatasciore (born June 15, 1967) is an American voice actor. Tatasciore was born in New York City, New York in 1967. He was a stand-up comedian before turning over to voice acting. Tatasciore has portrayed mostly secondary characters as well as monstrous-looking types. He is best known for voicing the Hulk in countless animated roles, including Ultimate Avengers, Next Avengers, Hulk Vs, Marvel Ultimate Alliance 2 and Avengers: Earth's Mightiest Heroes. In video games, he is known for voicing Saren Arterius from the critically acclaimed series Mass Effect and Damon Baird in the Gears of War video game series, and Zeratul from the game StarCraft II: Wings of Liberty. He also voices the character "8" in the Tim Burton-produced film 9 that was released September 9, 2009. His most recent roles are of that as Neftin Prog in Ratchet & Clank: Into the Nexus, Russian Nikolai Belinski in Call of Duty: World at War and Call of Duty: Black Ops, Tookit in Thundercats, and the Business Cat in the webseries "Our New Electrical Morals", with episodes posted in the Cartoon Hangover YouTube page, administered by Frederator Studios.

Fred Tatasciore plays as Sudarikov (voice) in Star Trek: Lower Decks.
Fred Tatasciore is the top #8 member of the cast and appears in 8 episodes.