Lewis James Pullman (born January 29, 1993) is an American actor. His film credits include The Strangers: Prey at Night, Bad Times at the El Royale (both 2018), and Top Gun: Maverick (2022). On television, he starred as Major Major Major Major in Catch-22 and Rhett Abbott in Outer Range.

Lewis Pullman plays as Rhett Abbott in Lessons in Chemistry.
Lewis Pullman is the top #1 member of the cast and appears in 8 episodes.

Brianne Sidonie Desaulniers (born October 1, 1989), known professionally as Brie Larson, is an American actress and filmmaker. She appeared as a regular in the 2001 sitcom Raising Dad and briefly dabbled with a music career, releasing the album Finally Out of P.E. in 2005. Larson subsequently played supporting roles in the comedy films Hoot (2006), Scott Pilgrim vs. the World (2010), and 21 Jump Street (2012), and appeared as a sardonic teenager in the television series United States of Tara (2009–2011). Larson's breakthrough came with a leading role in the acclaimed independent drama Short Term 12 (2013), and she continued to take on supporting parts in the romance The Spectacular Now (2013) and the comedy Trainwreck (2015). For playing a kidnapping victim in the drama Room (2015), Larson won the Academy Award for Best Actress. The 2017 adventure film Kong: Skull Island marked her first big-budget release, after which she starred as Carol Danvers / Captain Marvel in the 2019 Marvel Cinematic Universe superhero films Captain Marvel and Avengers: Endgame. She will next star in and executive produce the comedy-drama series Lessons in Chemistry for Apple TV+, and once again play Captain Marvel in the superhero sequel The Marvels. Larson has co-written and co-directed two short films, and made her feature film directorial debut with the independent comedy-drama Unicorn Store (2017). For producing the virtual reality series The Messy Truth VR Experience (2020), she won a Primetime Emmy Award.

Brie Larson plays as Elizabeth Zott in Lessons in Chemistry.
Brie Larson is the top #2 member of the cast and appears in 5 episodes.

Aja Naomi King is an American actress. She appeared in several short films before landing guest roles on the CBS procedurals Blue Bloods and Person of Interest. Her big break came in 2012 when she was cast as new surgical intern Cassandra Kopelson on the CW drama Emily Owens, M.D. The series was canceled after a single season in 2013. She later starred in the Amazon Studios comedy pilot The Onion Presents: The News. King also played Wendell Pierce's daughter Abigayle in the independent film Four, released on September 13, 2013. Along with her castmates, she won a Los Angeles Film Festival Award for her role in this movie.

Aja Naomi King plays as Harriet Sloane in Lessons in Chemistry.
Aja Naomi King is the top #3 member of the cast and appears in 5 episodes.

Stephanie Koenig (born September 1, 1987) is an American film and television actress and writer, best known for creating the webseries "Stupid Idiots".

Stephanie Koenig plays as Fran Frask in Lessons in Chemistry.
Stephanie Koenig is the top #4 member of the cast and appears in 5 episodes.

Patrick R. Walker was born to Nicole Micheau and Patrick Walker Sr. on December 2, 1992, in Jacksonville, Florida. He is known for Ambush (2023), The Resident (2018-2019), and Lessons in Chemistry (2023).

Patrick R. Walker plays as Wakely in Lessons in Chemistry.
Patrick R. Walker is the top #5 member of the cast and appears in 5 episodes.