Chyler Leigh is an American actress, best known for her portrayal of Dr. Lexie Grey on Grey's Anatomy and Alex Danvers on Supergirl. Born in Charlotte, North Carolina and raised in Virginia Beach and Miami Beach, Chyler began her career in front of the camera at age 12 modeling for magazines and catalogues. Her success in print later led to national commercials for Coca Cola and Wendy's, among others. By age 16, she had already completed several pilots (ABC's Wilder Days (2000) and the WB's Saving Graces (1999)) at the onset. Aaron Spelling confirmed the young actress's talent when he hired her a few years ago as a series regular in the WB series Safe Harbor (1999) after seeing her performance on Saving Graces (1999). She also guest-starred on 7th Heaven (1996) in a powerful three-story arc wherein her character, "Frankie", a young, inept mother had adversely influenced the family. Leigh made her film debut in the Colombia/Tri-Star hit comedy spoof Not Another Teen Movie (2001), which opened nationwide December, 2001. She originally auditioned for a smaller role, but the producers and directors were so impressed with her performance that they invited her to read for the lead. Leigh was stunned by her good fortune. By January of 2002, Leigh had already landed a series role on the Fox comedy That '80s Show (2002) (from the producers of "That '70s Show"). The mid season comedy series portrayed Leigh as a rebellious teenager on the Fox Network. After the short-lived run, the series was canceled, and Leigh was immediately brought to executive producer David E. Kelley for consideration in his new Fox series Girls Club (2002). Three days later, Leigh was flown for the New York up-fronts where she was introduced as one of the new series leads, "Sarah Mickle", a young attorney, on Fox's 2002 Girls Club (2002). After only two episodes of Girls Club (2002) had aired, Leigh received a personal phone call from Kelley informing her of the show's cancellation and his desire to bring her forward to his already established series The Practice (1997). With only a matter of weeks between shows, Leigh was at work on the set of ABC's The Practice (1997) as "Claire Wyatt", a new Series Regular for the 2002-2003 season. In 2004, Leigh was reunited with Fox for their new half hour comedy pilot "Lucky Us". Chyler landed the starring role of the free-wheeling conservative young architect, "Lucy Reed". Weeks later, Leigh made a guest starring appearance as "Kate Spangler", a feisty young ad exec, in Fox's new drama series North Shore (2004)". Later in the season, Leigh took a brief break from Fox to shoot a series lead role opposite Billy Campbell in the WB's drama pilot Rocky Point (2005). The series was centered on a young woman (Leigh) living on Hawaii's North Shore who takes in her estranged father (Campbell).

Chyler Leigh plays as Alex Danvers in Supergirl.
Chyler Leigh is the top #1 member of the cast and appears in 106 episodes.

Melissa Benoist is an American actress and singer, known for her portrayal of "Marley Rose" on Glee and the title role in Supergirl. Furthermore, she has appeared in a number of television series, including Homeland, The Good Wife and Law & Order. Melissa's first film was in singer Mariah Carey's Tennessee (2008). She also appeared in Whiplash (2014), which won top prizes (Grand Jury and Audience awards) at the Sundance Film Festival in Park City, Utah, in January 2014

Melissa Benoist plays as Kara Danvers, Supergirl, Kara Zor-El in Supergirl.
Melissa Benoist is the top #2 member of the cast and appears in 106 episodes.

David Harewood is an English actor, known for playing David Estes in Homeland and Hank Henshaw in Supergirl.

David Harewood plays as J'onn J'onzz, Martian Manhunter in Supergirl.
David Harewood is the top #3 member of the cast and appears in 106 episodes.

Jeremy Michael Jordan (born November 20, 1984) is a Tony-nominated American actor and singer. He has performed on Broadway, in television and film, as well as in other theatrical productions. He is known for his role of 'Jamie' in the 2014 movie adaptation of the musical, 'The Last Five Years'. He has played the roles of Jack Kelly in the 2012 musical Newsies, Clyde Barrow in the 2011 musical Bonnie & Clyde, Dr. Pomatter in the musical Waitress, and Jamie Wellerstein in the 2014 film The Last Five Years. Beginning in 2015, he has played Winslow "Winn" Schott, Jr., the son of DC Comics villain character Toyman, on the CBS/CW DC Comics-based superhero drama series Supergirl.

Jeremy Jordan plays as Winn Schott in Supergirl.
Jeremy Jordan is the top #4 member of the cast and appears in 65 episodes.

Chris Wood is an actor known for The Vampire Diaries (2014), Supergirl (2016) and Legacies (2020).

Chris Wood plays as Mon-El in Supergirl.
Chris Wood is the top #5 member of the cast and appears in 45 episodes.

Born and raised in Montreal, Jesse Rath is best known for his role as Carter Boyd in the CBC series 18 to Life, for which he received a 2010 and 2011 Gemini Award nomination. Other small screen credits include lead roles in Mudpit and Disney Channel’s Aaron Stone as well as guest star appearances in Cra$h and Burn, My Babysitter’s a Vampire, and Being Human. Rath’s feature film credits include The Greatest Game Ever Played, Prom Wars, The Howling: Reborn and The Trotsky (opposite Jay Baruchel). Rath is a diehard comic book fan and when he isn’t working, he can be found scouring local stores around Los Angeles, Toronto and Montreal. He is also one of the creators and stars of the popular web series Fans. His sister is Canadian actress Meaghan Rath. He guest starred as her onscreen brother on the fellow Syfy show Being Human.

Jesse Rath plays as Querl Dox, Brainiac-5 in Supergirl.
Jesse Rath is the top #6 member of the cast and appears in 41 episodes.

Nicole Amber Maines (born October 7, 1997) is an American actress also known for being Susan Doe in the Maine Supreme Judicial Court case Doe v. Regional School Unit 26 regarding gender identity and bathroom use in schools. Description above from the Wikipedia article Nicole Maines, licensed under CC-BY-SA, full list of contributors on Wikipedia.

Nicole Maines plays as Nia Nal, Dreamer in Supergirl.
Nicole Maines is the top #7 member of the cast and appears in 41 episodes.

Odette Annable is an American film and television actress.

Odette Annable plays as Samantha Arias, Reign in Supergirl.
Odette Annable is the top #8 member of the cast and appears in 23 episodes.

Floriana Lima plays as Maggie Sawyer in Supergirl.
Floriana Lima is the top #9 member of the cast and appears in 22 episodes.

Calista Flockhart (born November 11, 1964) is an American actress who is primarily recognized for her work in television. She is best known for playing the title character in Ally McBeal, and her role as Cat Grant in Supergirl. During her career, she has received a Golden Globe Award, a Screen Actors Guild Award and three Emmy Award nominations.

Calista Flockhart plays as Cat Grant in Supergirl.
Calista Flockhart is the top #10 member of the cast and appears in 20 episodes.