Tiffany Sarac Haddish (born December 3, 1979) is an American comedian and actress. After guest starring on several television series, Haddish gained prominence as Jackie on the first season of the OWN television drama If Loving You Is Wrong from 2014 to 2015. From 2015 to 2017, she starred as Nekeisha Williams on the NBC sitcom The Carmichael Show. After appearing in the 2016 comedy film Keanu, Haddish made her film breakthrough as Dina in the 2017 film Girls Trip, for which she received critical acclaim. In 2018, Haddish was included on Time's annual list of the 100 most influential people in the world.

Tiffany Haddish plays as Tuca (voice) in Tuca & Bertie.
Tiffany Haddish is the top #1 member of the cast and appears in 30 episodes.

Steven Yeun (Korean: 연상엽; born Yeun Sang-yeop, December 21, 1983) is a South Korean-American actor. Yeun initially rose to prominence for his role as Glenn Rhee in the television series The Walking Dead (2010–2016). He later starred in and executive produced Minari (2020), earning him critical acclaim and a nomination for the Academy Award for Best Actor, becoming the first Asian American actor to be nominated in this category. Yeun has also appeared in the films I Origins (2014), Okja (2017), Mayhem (2017), Burning (2018), Sorry to Bother You (2018), and Nope (2022), and has voiced main characters in television series such as Voltron: Legendary Defender (2016–2018), Tuca & Bertie (2019), and Invincible (2021-present), among others.

Steven Yeun plays as Danny Cho in Tuca & Bertie.
Steven Yeun is the top #2 member of the cast and appears in 10 episodes.

John Early (born January 21, 1988) is an American comedian and actor. He has appeared on 30 Rock as Jenna Maroney's son and in the independent film Fort Tilden. He starred in Search Party, which aired on TBS and HBO Max from 2016 to 2022. Description above from the Wikipedia article John Early (comedian), licensed under CC-BY-SA, full list of contributors on Wikipedia.

John Early plays as Dirk (voice) in Tuca & Bertie.
John Early is the top #3 member of the cast and appears in 10 episodes.

Alexandra "Ali" Wong (born April 19, 1982) is an American actress, stand-up comedian, and writer. She is noted for her Netflix stand-up specials Baby Cobra and Hard Knock Wife, as well as her television roles in American Housewife, Are You There, Chelsea?, Inside Amy Schumer, and Black Box. She also wrote for the first three seasons of the sitcom Fresh Off the Boat.

Ali Wong plays as Amy Lau in Tuca & Bertie.
Ali Wong is the top #4 member of the cast and appears in 10 episodes.