Tisha Michelle Campbell (born October 13, 1968) is an American actress, comedian, singer and dancer. She made her screen debut appearing in the 1986 rock musical comedy film Little Shop of Horrors and has appeared in films including School Daze (1988), Rooftops (1989), Another 48 Hrs. (1990), Boomerang (1992), and Sprung (1997). On television, Campbell starred as Gina Waters-Payne in the Fox comedy series Martin from 1992 to 1997, Patrice Murphy in the WB comedy The Jamie Foxx Show (1996-2000) and as Janet "Jay" Marie Johnson-Kyle in the ABC comedy series My Wife and Kids (2001–2005), for which she received NAACP Image Award for Outstanding Actress in a Comedy Series.

Tisha Campbell-Martin plays as Suzanne Prentiss in Uncoupled.
Tisha Campbell-Martin is the top #1 member of the cast and appears in 8 episodes.

Neil Patrick Harris (born June 15, 1973) is an American actor, singer, writer, producer, and television host. Primarily known for his comedic television roles and dramatic and musical stage roles, he has received multiple accolades throughout his career, including a Tony Award, five Primetime Emmy Awards, and nominations for a Grammy Award and three Screen Actors Guild Awards. On television, he is known for playing the title character on the ABC series Doogie Howser, M.D. (1989–1993), for which he was nominated for the Golden Globe Award for Best Actor – Television Series Musical or Comedy, as well as Barney Stinson on the CBS series How I Met Your Mother (2005–2014, for which he was nominated for four Emmy Awards), and Count Olaf on the Netflix series A Series of Unfortunate Events (2017–2019). Harris is also known for his role as the title character in Joss Whedon's musical Dr. Horrible's Sing-Along Blog (2008) and a fictional version of himself in the Harold & Kumar film series (2004–2011). His other films include Starship Troopers (1997), Beastly (2011), The Smurfs (2011), The Smurfs 2 (2013), A Million Ways to Die in the West (2014), and Gone Girl (2014). In 2010, Harris won two awards at the 62nd Primetime Emmy Awards, winning for Outstanding Guest Actor in a Comedy Series for his guest appearance on Glee, and Outstanding Special Class Program for hosting the Tony Awards in 2009; he has won the latter award three additional times for hosting the show in 2011, 2012, and 2013. He also hosted the Primetime Emmy Awards in 2009 and 2013, and hosted the 87th Academy Awards in 2015, thus making him the first openly gay man to host the Academy Awards. In 2014, he starred in the title role in Hedwig and the Angry Inch on Broadway, for which he won the 2014 Tony Award for Best Leading Actor in a Musical. Harris was named one of Time magazine's 100 Most Influential People in 2010. He is married to David Burtka. In 2010, they had twins via surrogacy.

Neil Patrick Harris plays as Michael Lawson in Uncoupled.
Neil Patrick Harris is the top #2 member of the cast and appears in 8 episodes.

Emerson Brooks plays as Billy Burns in Uncoupled.
Emerson Brooks is the top #3 member of the cast and appears in 8 episodes.

Brooks Ashmanskas plays as Stanley James in Uncoupled.
Brooks Ashmanskas is the top #4 member of the cast and appears in 8 episodes.