Shin'ichirō Miki is a Japanese voice actor affiliated with 81 Produce and most known for his role as Kojiro (James) in Pokémon. Miki is also a singer with the four-man band Weiß, along with Takehito Koyasu, Tomokazu Seki, and Hiro Yūki, the four main voice actors of Weiß Kreuz. Miki is also very active in BL dramas. He won Best Actors in supporting roles in the 4th Seiyu Awards. He often gets cast as handsome, young men in anime roles.

Shin-ichiro Miki plays as Kojirou (voice) in Dorohedoro.
Shin-ichiro Miki is the top #1 member of the cast and appears in 1087 episodes.

Kenyu Horiuchi is a Japanese voice actor. In 2002 he founded his own voice acting management office, Kenyu Office.

Kenyu Horiuchi plays as Narrator (voice) in Dorohedoro.
Kenyu Horiuchi is the top #2 member of the cast and appears in 144 episodes.

Tooru Nara plays as Flazzard (voice) in Dorohedoro.
Tooru Nara is the top #3 member of the cast and appears in 94 episodes.

Yoshimasa Hosoya is a Japanese voice actor and singer from Hiroshima. He was represented by Mausu Promotion and is now a freelancer. He was also a member of the pop duo MaxBoys along with Toshiki Masuda, a fellow Japanese voice actor. In 2014 & 2016, he won the 8th Seiyu Awards & 10th Seiyu Awards for Best supporting actor. Among his many roles in anime, he voiced Kojou Akatsuki in Strike the Blood, Reiner Braun in Attack on Titan, Fumikage Tokoyami in My Hero Academia, Tamaki Katagiri in Black Bullet, Shichika Yasuri in Katanagatari, Daryun in The Heroic Legend of Arslan, Belial in Granblue Fantasy, and Orga Itsuka in Mobile Suit Gundam: Iron-Blooded Orphans. He also appears in many sports anime as Junpei Hyūga in Kuroko's Basketball, Sosuke Yamazaki in Free! Eternal Summer, Asahi Azumane in Haikyuu!!, Tetsuya Yuki in Ace of Diamond and Otabek Altin in Yuri!!! on Ice. On April 23, 2017, he announced a hiatus to undergo treatment for his throat. On August 4, 2017, he announced his return to voice work.

Yoshimasa Hosoya plays as Asahi Azumane (voice) in Dorohedoro.
Yoshimasa Hosoya is the top #4 member of the cast and appears in 85 episodes.

Takehito Koyasu is a Japanese voice actor. Koyasu is part of the voice actor quartet Weiß consisting of Weiß Kreuz voice castmates Shinichiro Miki, Tomokazu Seki, and Hiro Yūki. He used to work for Production Baobab but is now the head of T's Factory, a voice actor company he founded in 1998. Koyasu is known for his deep, smooth voice, which often lands him in roles that are either villains or lonely bishōnen. Recently, though (as in the cases of Mitsurugi Hanagata from Saber Marionette J, Ryo Kuroyanagi from Yakitate!! Japan, Bobobo-bo Bo-bobo, and Kei Itoshiki from (Zoku) Sayonara, Zetsubou-Sensei) he has been voicing more and more lively/humorous characters. According to Hisaya Nakajo, the manga artist of the series Hana-Kimi, the character of Masao Himejima was designed with Koyasu's voice in mind; the voice actor ended up voicing this character in the series' drama CDs. On 18 September 2009, he created Velvet Underworld series which is the first drama CD of the series, "The Fool". In the following month, "The Wheel of Fortune" had released as the second drama CD of the series.

Takehito Koyasu plays as Dio Brando (voice), DIO (voice) in Dorohedoro.
Takehito Koyasu is the top #5 member of the cast and appears in 74 episodes.

Yuki Kaji is a Japanese voice actor and singer affiliated with the agency VIMS. He has also been a radio host and acted on stage, and since 2015 has also occasionally been cast in on-screen roles in television dramas. He has voiced many notable roles such as Eren Yeager in Attack on Titan, Issei Hyodo in High School DxD, Shu Ouma in Guilty Crown, Alibaba in Magi: The Labyrinth of Magic, Kazuya Ichinose and Akio Fudou in Inazuma Eleven: Orion no Kokuin, Clemont in Pokémon XY, Meliodas and Zeldris in The Seven Deadly Sins, Yukine in Noragami, Speed-O'Sound Sonic in One-Punch Man, Kanato Sakamaki in Diabolik Lovers, Todoroki Shōto in My Hero Academia, Kozume Kenma in Haikyu!!, Koichi Hirose in JoJo's Bizarre Adventure.

Yuki Kaji plays as Koichi Hirose (voice) in Dorohedoro.
Yuki Kaji is the top #6 member of the cast and appears in 39 episodes.

Wataru Takagi (高木 渉) is a Japanese voice and stage actor.

Wataru Takagi plays as Okuyasu Nijimura (voice) in Dorohedoro.
Wataru Takagi is the top #7 member of the cast and appears in 39 episodes.

Hisao Egawa (江川 央生, Egawa Hisao, September 13, 1962) is a Japanese actor, voice actor, and narrator. He is from Tokyo and is attached to Aoni Production.

Hisao Egawa plays as Keishin Ukai (voice) in Dorohedoro.
Hisao Egawa is the top #8 member of the cast and appears in 25 episodes.

Takuma Terashima (寺島 拓篤, Terashima Takuma) is a Japanese voice actor and singer born in Ishikawa, Japan. Terashima graduated from Tokyo Announce Gakuin, voice training school. He had initially belonged to Holypeak until December 2008, and then to Production Baobab up until September 2011 when he switched to Axlone, Toshiyuki Morikawa's own agency. He is married to voice actress Satomi Satō. Ishikawa Yuusuke is an alias Terashima Takuma has used when working on adult games/anime.

Takuma Terashima plays as Von Tepes in Dorohedoro.
Takuma Terashima is the top #9 member of the cast and appears in 21 episodes.

Kengo Takanashi (高梨 謙吾, Takanashi Kengo, born on June 12, 1986) is a Japanese voice actor from Tokyo. He is currently affiliated with Arts Vision. He uses the stagename Ootori Yuuji when voice acting for adult anime.

Kengo Takanashi plays as Akiya Shirakawa (voice) in Dorohedoro.
Kengo Takanashi is the top #10 member of the cast and appears in 13 episodes.