Louie runs into an old acquaintance.

The episode was rated 7.62 from 526 votes.

After leaving his girls with their mother for a week, Louie tries to cope with their absence. He initially plans on exercising, but ends up eating ice cream and pizza for two days. Later, he's pressured into smoking pot with his obnoxious neighbor and decides to get an adult dog, which promptly dies. After Animal Control picks up the dog to dispose of it, Louie's girls return and he tells them he had a good weekend.

The episode was rated 7.62 from 408 votes.

Louie waits at Grand Central Station to pick up his sister and niece for a visit. However, his sister surprises him by dumping the niece Amy on him and running off to catch a train to Philadelphia. Louie and Amy spend the night in New York together, visiting an indie rock club at her request, after which she asks to see Louie perform. After seeing her enamored with Godfrey's set, Louie attempts, unsuccessfully, to impress his niece by doing crowd work. After the set, Louie is surprised to see Godfrey spark up a lively conversation with the usually sullen teen. When they arrive back at the apartment, Louie receives a call from a Philadelphia hospital informing him that Amy's mother was found "acting irrationally" in a public fountain and that she is being held under observation. With Amy's father out of the picture, Louie volunteers to keep Amy until his sister is released.

The episode was rated 7.59 from 316 votes.

The episode begins in a flashback with Louie filming the pilot for a sitcom. After complaining about the unrealistic dialogue and use of Bob Saget as the next door neighbor, Louie is shown arriving home to an unseen and presumably upset wife and their newborn baby Lilly. The episode then jumps to Lilly's tenth birthday. Louie sets out to obtain Lady GaGa concert tickets as a birthday present for his daughter, but doing so means he has to approach Dane Cook, a very successful comedian who is upset by accusations he has stolen material from Louie.

The episode was rated 7.58 from 337 votes.

Louie continues his work on the road.

The episode was rated 7.57 from 446 votes.

Louie goes on the road.

The episode was rated 7.56 from 468 votes.

Louie deals with a rash.

The episode was rated 7.53 from 331 votes.

During a stand up routine, Louie discusses serious topics such as child abuse and abduction. In the first segment, Louie goes to a new dentist who's afraid of dentists himself and specializes in calming patients fears. Louie is anesthetized and provided with middle eastern music. While under, he dreams about speaking with Osama Bin Laden and a group of terrorists. The group discuss ethics and the 9/11 attacks. Louie then dreams that the dentist is putting a banana in his mouth. When he wakes up he finds the dentist frantically zipping his pants, implying that Louie was orally raped. While performing stand up, Louie discusses the intricacies of male sexuality. In a second segment, he attempts to court a black woman named Tarese who works at the local grocery store. After buying groceries, Louie buys the woman flowers (from the same store), checks out at her register, and then gives the flowers to her. Tarese calls the manager to complain and the manager reimburses Louie for the flowers. Louie is waiting for the woman when she gets off of work, and walks home with her. Although Tarese is openly not interested, Louie walks with her to her apartment, where he is turned down. He then meets her sister as she is leaving the apartment complex. The next scene shows the two performing coitus. In a closing stand up segment, Louie professes his love for Jewish women.

The episode was rated 7.49 from 377 votes.

When a nun at his Catholic school feels a young Louie and his friend aren't sufficiently penitent over Christ's suffering on the cross, a visiting doctor is brought in to give a graphic, medically specific description of the event, which haunts and frightens Louie. But Louie's mother turns up in a new incarnation as a wise and loving parent who tells Louie that relying on dogma isn't the best way to be a good person.

The episode was rated 7.46 from 375 votes.

In the first segment, Louie volunteers to chaperon his daughter's field trip along with her teacher, which a surly bus driver helps turn into a disaster. In the second segment, Louie goes on an awkward and unsuccessful first date.

The episode was rated 7.39 from 758 votes.