Michael Gerard Tyson (born June 30, 1966) is an American former professional boxer, competing from 1985 to 2005. He reigned as the undisputed world heavyweight champion, and holds the record as the youngest boxer to win a heavyweight title, at 20 years, four months, and 22 days old. From Wikipedia, the free encyclopedia

Mike Tyson plays as Mike Tyson in Mike Tyson Mysteries.
Mike Tyson is the top #1 member of the cast and appears in 69 episodes.

Norman Gene Macdonald (October 17, 1959 – September 14, 2021) was a Canadian stand-up comedian, writer, and actor known for his deadpan style. Early in his career, he wrote for the sitcom Roseanne and made guest appearances on shows such as The Drew Carey Show and NewsRadio. Macdonald was then a cast member on Saturday Night Live (SNL) for five years, including anchoring the Weekend Update segment for three seasons. After leaving SNL, he starred in the 1998 film Dirty Work and in his own sitcom, The Norm Show, from 1999 to 2001. In 2013, Macdonald started a video podcast, Norm Macdonald Live, on which he interviewed comedians and other celebrities. In 2018, he released Norm Macdonald Has a Show, a Netflix talk show with a similar premise to his podcast. Throughout his career, Macdonald had appeared in numerous movies and been a guest on talk shows such as Conan, Late Night with David Letterman, and The Howard Stern Show. He had also worked as a voice actor, notably on the animated show Mike Tyson Mysteries. Paste magazine named him #31 on their 50 Best Stand-up Comics of All Time. Description above from the Wikipedia article Norm Macdonald, licensed under CC-BY-SA, full list of contributors on Wikipedia.

Norm Macdonald plays as Pigeon in Mike Tyson Mysteries.
Norm Macdonald is the top #2 member of the cast and appears in 69 episodes.

Rachel Ramras plays as Yung Hee Tyson in Mike Tyson Mysteries.
Rachel Ramras is the top #3 member of the cast and appears in 69 episodes.

Jim Rash was born in Charlotte, North Carolina and is an American actor, comedian and screenwriter. His most noticeable appearance was when he portrayed Mr Grayson/Stitches, a sidekick to the supervillain 'Royal Pain' in the 2005 film Sky High and as the recurring characters Fenton on That '70s Show and "Andrew the Whore House Guy" on Reno 911!. He also guest starred in the last episode of Friends, and played the role of Head T.A. Philip in Slackers. Rash currently has a recurring role in Community as Dean Pelton. Rash and comedy partner Nat Faxon have recently moved into screenwriting.

Jim Rash plays as Marquess of Queensberry in Mike Tyson Mysteries.
Jim Rash is the top #4 member of the cast and appears in 69 episodes.