Demetria McKinney plays as Ada Monroe in The Winchesters.
Demetria McKinney is the top #1 member of the cast and appears in 10 episodes.

Meg Elizabeth Donnelly is an American actress. She is known for playing Ash in Netflix comedy series Team Toon, and for starring as Taylor Otto in the ABC sitcom American Housewife since 2016. In February 2018, Donnelly starred as Addison in the Disney Channel Original Movie Zombies.

Meg Donnelly plays as Mary Campbell in The Winchesters.
Meg Donnelly is the top #2 member of the cast and appears in 10 episodes.

Drake Rodger is known for The Winchesters (2022), The In Between (2022) and Quiet In My Town.

Drake Rodger plays as John Winchester in The Winchesters.
Drake Rodger is the top #3 member of the cast and appears in 10 episodes.

Nida Khurshid plays as Latika Desai in The Winchesters.
Nida Khurshid is the top #4 member of the cast and appears in 10 episodes.

Jensen Ross Ackles (born March 1, 1978) is an American actor. He is most notable for his television role as Dean Winchester on the CW television series Supernatural. His other popular roles include Soldier Boy on the popular Amazon Prime original series The Boys, Eric Brady in Days of our Lives which earned him several Daytime Emmy Award nominations, Alec/X5-494 in Dark Angel, and Jason Teague in Smallville.

Jensen Ackles plays as Dean Winchester (voice) in The Winchesters.
Jensen Ackles is the top #5 member of the cast and appears in 10 episodes.

Jojo Fleites plays as Carlos Cervantez in The Winchesters.
Jojo Fleites is the top #6 member of the cast and appears in 10 episodes.

Bianca Maria Kajlich (KY-lik; born March 26, 1977) is an American actress, best known for her role as Jennifer on CBS's sitcom Rules of Engagement (2007–2013). She began her career with the Olympic Ballet Theater as a ballet dancer in Edmonds, Washington. After seven years, she decided to try acting. By that time, she had already performed lead roles in The River, Swan Lake, and The Nutcracker. Her first acting part was in an advertisement for Kragen Auto Parts. She has since appeared in the films Bring It On, 10 Things I Hate About You, Halloween: Resurrection, and 30 Minutes Or Less. She also had recurring roles in the television series Boston Public as Lisa Grier and in Dawson's Creek as Natasha Kelly, as well as roles in UPN's Rock Me Baby and the Fox drama Vanished. She was ranked No. 74 on the Maxim "Hot 100 Women of 2004" and No. 63 on the Maxim "Hot 100 Women of 2007". In March 2013, she was cast as a main character in the NBC sitcom Undateable (2014-2016). In October 2017, she appeared as Paula, a prostitute befriended with sartorial advice by Larry David in HBO's Curb Your Enthusiasm. She starred as Christina Henry on the Amazon Prime series Bosch.

Bianca Kajlich plays as Millie Winchester in The Winchesters.
Bianca Kajlich is the top #7 member of the cast and appears in 10 episodes.