Mike Henry is an American voice actor, writer, producer, and comedian. He is known for his work on the animated TV series Family Guy (1999–present), where he writes and produces episodes along with voicing Cleveland Brown, Herbert, Bruce, and Consuela. Henry is also known for co-creating and starring in the spin-off, The Cleveland Show (2009–2013) and for his recurring role as Dann in the television series, The Orville.

Mike Henry plays as Cleveland Brown, Herbert, Bruce, Consuela, Greased-Up Deaf Guy, Cleveland Brown (voice) in The Orville.
Mike Henry is the top #1 member of the cast and appears in 359 episodes.

Norman Gene Macdonald (October 17, 1959 – September 14, 2021) was a Canadian stand-up comedian, writer, and actor known for his deadpan style. Early in his career, he wrote for the sitcom Roseanne and made guest appearances on shows such as The Drew Carey Show and NewsRadio. Macdonald was then a cast member on Saturday Night Live (SNL) for five years, including anchoring the Weekend Update segment for three seasons. After leaving SNL, he starred in the 1998 film Dirty Work and in his own sitcom, The Norm Show, from 1999 to 2001. In 2013, Macdonald started a video podcast, Norm Macdonald Live, on which he interviewed comedians and other celebrities. In 2018, he released Norm Macdonald Has a Show, a Netflix talk show with a similar premise to his podcast. Throughout his career, Macdonald had appeared in numerous movies and been a guest on talk shows such as Conan, Late Night with David Letterman, and The Howard Stern Show. He had also worked as a voice actor, notably on the animated show Mike Tyson Mysteries. Paste magazine named him #31 on their 50 Best Stand-up Comics of All Time. Description above from the Wikipedia article Norm Macdonald, licensed under CC-BY-SA, full list of contributors on Wikipedia.

Norm Macdonald plays as Pigeon in The Orville.
Norm Macdonald is the top #2 member of the cast and appears in 69 episodes.

Scott Grimes (born July 9, 1971) is an American actor, voice artist and musician. Some of his most prominent roles are his appearances on ER, Party of Five, Band of Brothers, and American Dad.

Scott Grimes plays as Gordon Malloy in The Orville.
Scott Grimes is the top #3 member of the cast and appears in 26 episodes.

Adrianne Palicki (born May 6, 1983) is an American actress best known for her role as Tyra Collette on the NBC television series Friday Night Lights. 

Adrianne Palicki plays as Kelly Grayson in The Orville.
Adrianne Palicki is the top #4 member of the cast and appears in 26 episodes.

Penny Johnson Jerald (born March 14, 1961, height 5' 5" (1,65 m) ) is an American actress. She played Beverly Barnes on the HBO comedy series The Larry Sanders Show, Kasidy Yates on the syndicated science fiction series Star Trek: Deep Space Nine, Sherry Palmer on the Fox action/drama series 24 and Captain Victoria "Iron" Gates on the ABC comedy-drama series Castle.

Penny Johnson plays as Claire Finn in The Orville.
Penny Johnson is the top #5 member of the cast and appears in 26 episodes.

Peter Macon plays as Bortus in The Orville.
Peter Macon is the top #6 member of the cast and appears in 26 episodes.

J. Lee plays as John LaMarr in The Orville.
J. Lee is the top #7 member of the cast and appears in 26 episodes.

Mark Jackson plays as Isaac in The Orville.
Mark Jackson is the top #8 member of the cast and appears in 26 episodes.

Seth Woodbury MacFarlane (born October 26, 1973) is an American animator, writer, comedian, producer, actor, singer, voice actor, and director best known for creating the animated sitcoms Family Guy, American Dad! and The Cleveland Show, for which he also voices many of the shows' various characters. A native of Kent, Connecticut, MacFarlane is a graduate of the Rhode Island School of Design, where he studied animation, earning a Bachelor of Fine Arts Degree. He was an animator and writer for Hanna-Barbera for several television shows, including Johnny Bravo, Cow and Chicken and Dexter's Laboratory, before creating his own series for 20th Century Fox entitled Family Guy in 1999. MacFarlane would go on to co-create American Dad! in 2005, The Winner in 2007 and The Cleveland Show in 2009 for 20th Century Fox. As an actor, he has made guest appearances on shows such as Gilmore Girls, The War at Home and FlashForward. MacFarlane's interest in science fiction and fantasy has led to cameo and guest appearances on Star Trek: Enterprise and voicing the character of Johann Kraus in Guillermo del Toro's Hellboy II: The Golden Army. In 2008, he created his own YouTube series entitled Seth MacFarlane's Cavalcade of Cartoon Comedy. As a performer, MacFarlane has sung at several venues, including Carnegie and Royal Albert Hall. MacFarlane has won several awards for his work on Family Guy, including two Primetime Emmy Awards, and an Annie Award. In 2009, he won the Webby Award for Film & Video Person of the Year. He has been a subject of criticism from television watchdog groups, such as the Parents Television Council, who regularly condemn Family Guy for its indecency. He occasionally speaks at universities and colleges throughout the United States, and is a supporter of gay rights. On the February 10, 2011 episode of the TBS variety nighttime talk-show series Conan, MacFarlane announced he is directing his first feature-length film, Ted. The film stars Mark Wahlberg as an adult, who as a child, wished his teddy bear would come to life. MacFarlane will be the voice and motion capture for the bear.

Seth MacFarlane plays as Lion-O in The Orville.
Seth MacFarlane is the top #9 member of the cast and appears in 20 episodes.

Jessica Karen Szohr (born March 31, 1985) is an American actress. Szohr began her screen career starring on television shows such as CSI: Miami and What About Brian. She gained recognition in 2007 with her breakthrough role as Vanessa Abrams on The CW series Gossip Girl. Description above from the Wikipedia article Jessica Szohr, licensed under CC-BY-SA, full list of contributors on Wikipedia.

Jessica Szohr plays as Talla Keyali in The Orville.
Jessica Szohr is the top #10 member of the cast and appears in 14 episodes.