Grey's Anatomy

10 Best Episodes of Grey's Anatomy - Season 10

Grey's Anatomy has been a fan favorite since its debut in 2005. The show follows the personal and professional lives of a group of doctors at Seattle’s Grey Sloan Memorial Hospital, delivering drama, romance, and heartbreak in equal measure. With 22 seasons under its belt, the show has had its fair share of standout moments and fan-favorite episodes.

To celebrate the show's success, we've compiled a list of the best episodes ranked by viewers. From shocking twists to heartwarming moments, these episodes are sure to leave you on the edge of your seat. Whether you're a long-time fan or a newcomer to the series, these episodes are a must-watch for any Grey's Anatomy enthusiast.

So sit back, grab some popcorn, and get ready to relive some of the most iconic moments from Grey's Anatomy. With its gripping storylines, talented cast, and unforgettable characters, it's no wonder the show has remained a staple of primetime TV for over 15 years.

Written by Sophie and last updated on may 04, 2024.

PS: The following content contains spoilers!

PPS: I will admit that parts of this page was written with the help of AI - it makes my work so much easier to not start from a blank page!

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Grey's Anatomy - S10E16

#15 - We Gotta Get Out of This Place (Season 10 - Episode 16)

It's Richard's birthday and Bailey invites him to scrub in on the case of a lifetime. Meredith hires a research assistant to help with her portal vein project. A scorned Callie gives Derek quite the shock. Meanwhile, Shane helps screen candidates for Cristina's clinical trial and meets a young expectant mother who needs his help.

The episode was rated 7.75 from 996 votes.

Grey's Anatomy - S10E4

#14 - Puttin' on the Ritz (Season 10 - Episode 4)

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The doctors of Grey Sloan Memorial throw a fundraising gala which turns wildly competitive after Jackson makes a rash promise. Back at the hospital, Bailey’s patience is tested when she has to deal with several extremely difficult patients. Meanwhile, Shane and Stephanie handle an incredibly busy ER by themselves and Alex reveals an emotional secret to Jo.

The episode was rated 7.76 from 1025 votes.

Grey's Anatomy - S10E23

#13 - Everything I Try to Do, Nothing Seems to Turn Out Right (Season 10 - Episode 23)

With Derek away, Meredith spends time with Amelia and finds out her true feelings about her time in Seattle. Bailey deals with the ramifications of her actions and Callie receives devastating news. Meanwhile, the residents panic after hearing that one of them will be fired

The episode was rated 7.82 from 1007 votes.

Grey's Anatomy - S10E15

#12 - Throwing it All Away (Season 10 - Episode 15)

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Arizona has a bad day which escalates when she advises one of Callie's patients on a potential double amputation. Derek goes back on a promise to Callie, and Jo and Stephanie come across an abandoned baby outside the hospital. Meanwhile, the doctors deal with the repercussions of the non-fraternization rule, which include meetings with HR and one doctor's suspension.

The episode was rated 7.83 from 1028 votes.

Grey's Anatomy - S10E14

#11 - You've Got to Hide Your Love Away (Season 10 - Episode 14)

After an anonymous complaint is issued by one of their own, the hospital implements a non-fraternizing policy causing the couples to panic. Meanwhile, Emma and Owen talk about the future, Cristina and Meredith enjoy a little girl time, and Richard enlists the residents to help research a rare cancer case.

The episode was rated 7.85 from 1007 votes.

Grey's Anatomy - S10E9

#10 - Sorry Seems to Be the Hardest Word (Season 10 - Episode 9)

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When an unexpected malpractice suit turns Callie's world upside down, her supportive father arrives and shares an interesting secret with her. Meanwhile, through flashbacks, we learn some surprising details about Callie and Arizona's marriage.

The episode was rated 7.87 from 1007 votes.

Grey's Anatomy - S10E19

#9 - I'm Winning (Season 10 - Episode 19)

Cristina won't let herself get excited when she is nominated for a Harper Avery award; Alex thinks about making a change; Callie and Derek work with a machine that recognizes emotions.

The episode was rated 7.87 from 994 votes.

Grey's Anatomy - S10E21

#8 - Change of Heart (Season 10 - Episode 21)

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Jackson is given the daunting task of delivering disappointing news to the doctors. Meanwhile, Derek's sister Amelia drops by for a surprise visit, Richard surprises Catherine in Boston and when Bailey gets frustrated by the slow pace of her research, she makes a risky decision.

The episode was rated 7.88 from 1009 votes.

Grey's Anatomy - S10E20

#7 - Go It Alone (Season 10 - Episode 20)

Cristina enlists Meredith to help her prepare an acceptance speech for her possible Harper Avery win and while Owen offers to attend the ceremony with her, she insists on going alone. Meanwhile, Derek feels overwhelmed between his responsibilities at home and at the hospital. April and Jackson come to a disagreement on children and religion, and Callie and Arizona try to reconnect in their marriage.

The episode was rated 7.91 from 1001 votes.

Grey's Anatomy - S10E13

#6 - Take It Back (Season 10 - Episode 13)

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The doctors are faced with the consequences of the events at April's wedding. Alex reacts to the news about his father. Callie and Arizona make a decision about their relationship.

The episode was rated 7.92 from 1011 votes.

Grey's Anatomy - S10E1

#5 - Seal Our Fate (Season 10 - Episode 1)

The Grey Sloan Memorial Hospital doctors are faced with the devastation left by the storm. A giant mudslide in Seattle injures a group of first responders and citizens, causing the already short handed ER to spring into action. Meanwhile, Meredith is faced with a tough decision that will affect the life of a loved one, Callie is rocked by the reality of Arizona’s infidelity, and Richard’s life is in extreme danger.

The episode was rated 7.95 from 1041 votes.

Grey's Anatomy - S10E2

#4 - I Want You with Me (Season 10 - Episode 2)

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Callie makes a decision about her relationship; the doctors receive devastating news.

The episode was rated 7.97 from 708 votes.

Grey's Anatomy - S10E22

#3 - We Are Never Ever Getting Back Together (Season 10 - Episode 22)

Cristina considers her future at the hospital; Amelia and Derek collaborate on a tough surgery involving conjoined twins; Jo takes on too many cases at once; Stephanie stumbles on the truth about Bailey's case.

The episode was rated 8.06 from 1022 votes.

Grey's Anatomy - S10E12

#2 - Get Up, Stand Up (Season 10 - Episode 12)

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In the Grey's Anatomy episode "Get Up, Stand Up," the day of April's wedding is anything but smooth sailing for the doctors at Grey Sloan Memorial. While April prepares to say "I do," the rest of the staff is consumed by their own personal dramas. Meredith and Cristina, once inseparable, find themselves clashing over their research and career paths. The tension between them reaches new heights, leaving viewers on the edge of their seats.

Meanwhile, Bailey finds herself in a difficult position as she confesses her feelings to Ben about his decision to move back to Seattle. Will their relationship withstand the strain of this revelation? And then there's Shane, who puts himself in a risky situation that threatens his future at the hospital. Will his guilt catch up to him and lead to his downfall?

As if that wasn't enough, Derek receives a life-changing phone call that promises to shake up his world. With major plot developments and emotional turmoil for most of the couples, this episode is bound to leave fans buzzing. Brace yourself for the fallout from Mer and Cristina's explosive fight, and keep an eye out for poor Alex, who finds himself brokenhearted. "Get Up, Stand Up" is a rollercoaster ride of emotions that you won't want to miss.

The episode was rated 8.24 from 1065 votes.

Grey's Anatomy - S10E24

#1 - Fear (of the Unknown) (Season 10 - Episode 24)

In the Grey's Anatomy episode titled "Fear (of the Unknown)," viewers are taken on an emotional rollercoaster as the doctors of Grey Sloan Memorial Hospital say goodbye to the beloved Cristina Yang. Fans of the show are left wondering what the future holds without her. But that's not all - chaos ensues at the hospital when a possible act of terrorism rocks Seattle. The tension is palpable as the doctors try to navigate through this unexpected crisis.

Amidst the chaos, Meredith, one of the show's central characters, makes a life-changing decision. What could it be? Viewers are left on the edge of their seats, eagerly awaiting the revelation. And if that wasn't enough, one doctor receives shocking news that will surely have a ripple effect on the lives of those around them. The episode leaves us with more questions than answers, ensuring that fans will be eagerly anticipating the next installment.

While some viewers express their emotional wreck over Cristina's departure, others contemplate whether they will continue watching the show. However, despite the mixed reactions, it's hard to deny that this episode packs a punch. From the intense storyline to the unexpected twists, Grey's Anatomy delivers yet again, proving why it has remained a fan favorite for so many years. So, buckle up and get ready for a thrilling and emotional ride in "Fear (of the Unknown)."

The episode was rated 8.30 from 1070 votes.

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