Grey's Anatomy

10 Best Episodes of Grey's Anatomy - Season 21

Grey's Anatomy has been a fan favorite since its debut in 2005. The show follows the personal and professional lives of a group of doctors at Seattle’s Grey Sloan Memorial Hospital, delivering drama, romance, and heartbreak in equal measure. With 22 seasons under its belt, the show has had its fair share of standout moments and fan-favorite episodes.

To celebrate the show's success, we've compiled a list of the best episodes ranked by viewers. From shocking twists to heartwarming moments, these episodes are sure to leave you on the edge of your seat. Whether you're a long-time fan or a newcomer to the series, these episodes are a must-watch for any Grey's Anatomy enthusiast.

So sit back, grab some popcorn, and get ready to relive some of the most iconic moments from Grey's Anatomy. With its gripping storylines, talented cast, and unforgettable characters, it's no wonder the show has remained a staple of primetime TV for over 15 years.

Written by Sophie and last updated on jan 14, 2025.

PS: The following content contains spoilers!

PPS: I will admit that parts of this page was written with the help of AI - it makes my work so much easier to not start from a blank page!

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Grey's Anatomy - S21E5

#8 - You Make My Heart Explode (Season 21 - Episode 5)

During a high-stress day at Grey Sloan Memorial, the fates of a patient in critical condition and a helicopter-bound medical team hang in the balance. Teddy and Owen work on their marriage, while Bailey, Blue and Link treat a hospital employee.

The episode was rated 7.29 from 238 votes.

Grey's Anatomy - S21E2

#7 - Take Me to Church (Season 21 - Episode 2)

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Meredith and Catherine continue to disagree, and Meredith confides in Bailey for support. Richard, Winston and Lucas spend the day outside of the hospital, and Blue deals with a relationship from his past. Levi meets the new hospital chaplain.

The episode was rated 7.29 from 273 votes.

Grey's Anatomy - S21E1

#6 - If Walls Could Talk (Season 21 - Episode 1)

After firing some of Grey Sloan's best, Catherine continues to interfere with Meredith and Amelia's research. Accidents at a climate change protest bring unique cases to the hospital, and Bailey encounters a blast from the past.

The episode was rated 7.36 from 295 votes.

Grey's Anatomy - S21E8

#5 - Drop It Like It's Hot (Season 21 - Episode 8)

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In the midst of a deadly heat wave, the team at Grey Sloan struggles to keep up with an overwhelming amount of patients. Amelia and Winston face a challenging surgery, while Jo and Lucas run an errand for the hospital that takes an unexpected turn.

The episode was rated 7.38 from 208 votes.

Grey's Anatomy - S21E4

#4 - This One's for the Girls (Season 21 - Episode 4)

Mika struggles with a life-altering personal matter. Meanwhile, Bailey and Ben navigate their personal and professional roles, while Levi finds a connection in an unlikely place. Jo and Link get surprising news.

The episode was rated 7.39 from 244 votes.

Grey's Anatomy - S21E3

#3 - I Can See Clearly Now (Season 21 - Episode 3)

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Simone and Lucas work to balance their relationship while competing to assist on an awake kidney transplant. Teddy offers Amelia a new opportunity, and Ben's interview doesn't go as planned. Meredith's secret causes tension with Richard.

The episode was rated 7.43 from 269 votes.

Grey's Anatomy - S21E6

#2 - Night Moves (Season 21 - Episode 6)

Teddy and Owen plan a date night that gets derailed in more ways than one, while Jo struggles to do it all at home. Mika adds more to her plate to make up for taking time off to be with her sister, and Levi is faced with a monumental decision.

The episode was rated 7.48 from 230 votes.

Grey's Anatomy - S21E7

#1 - If You Leave (Season 21 - Episode 7)

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The doctors at Grey Sloan must put aside their emotions under intense circumstances. Levi asks James a shocking question that could impact their future.

The episode was rated 7.55 from 223 votes.

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