Grey's Anatomy

10 Best Episodes of Grey's Anatomy - Season 6

Grey's Anatomy has been a fan favorite since its debut in 2005. The show follows the personal and professional lives of a group of doctors at Seattle’s Grey Sloan Memorial Hospital, delivering drama, romance, and heartbreak in equal measure. With 22 seasons under its belt, the show has had its fair share of standout moments and fan-favorite episodes.

To celebrate the show's success, we've compiled a list of the best episodes ranked by viewers. From shocking twists to heartwarming moments, these episodes are sure to leave you on the edge of your seat. Whether you're a long-time fan or a newcomer to the series, these episodes are a must-watch for any Grey's Anatomy enthusiast.

So sit back, grab some popcorn, and get ready to relive some of the most iconic moments from Grey's Anatomy. With its gripping storylines, talented cast, and unforgettable characters, it's no wonder the show has remained a staple of primetime TV for over 15 years.

Written by Sophie and last updated on may 04, 2024.

PS: The following content contains spoilers!

PPS: I will admit that parts of this page was written with the help of AI - it makes my work so much easier to not start from a blank page!

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Grey's Anatomy - S6E4

#15 - Tainted Obligation (Season 6 - Episode 4)

When Meredith and Lexie's father, Thatcher, returns to the hospital with a failed liver, it's up to Meredith to save his life. Meanwhile, Izzie empathizes with a patient riddled with tumors, as Mark, annoyed with Cristina's competitive zeal, tricks her into assisting on an unusual surgery.

The episode was rated 7.74 from 638 votes.

Grey's Anatomy - S6E3

#14 - I Always Feel Like Somebody's Watchin' Me (Season 6 - Episode 3)

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Several weeks after her near-death experience, a recovering Izzie returns to work. Meanwhile, nervous that there will be layoffs in the hospital in the wake of an announcement from the Chief, the Seattle Grace residents compete to survive the cuts, including Cristina, who attempts to work alongside Arizona in pediatrics. And Bailey and Alex's patient's already complex case is further complicated by her schizophrenic son.

The episode was rated 7.74 from 636 votes.

Grey's Anatomy - S6E22

#13 - Shiny Happy People (Season 6 - Episode 22)

An elderly patient admitted into the E.R. for a heart condition sees a familiar face, a long lost love who happens to be in the E.R. as well for a fractured arm, and the staff find themselves caught up in their love story. Meanwhile, Karev treats a troubled teenage patient (guest star Demi Lovato) whose parents brought her in for schizophrenia, and Meredith can't help but tell Cristina about her suspicions of Owen -- which inevitably messes with Cristina's head.

The episode was rated 7.75 from 601 votes.

Grey's Anatomy - S6E16

#12 - Perfect Little Accident (Season 6 - Episode 16)

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When famous surgeon Dr. Harper Avery is rushed to Seattle Grace-Mercy West, the staff is surprised to discover that one of their own is related to this legend, and his unorthodox request for his surgery causes tensions t between Derek and Richard. Meanwhile Callie and Arizona try to help Teddy and Sloan move on from their pasts and find greener pastures.

The episode was rated 7.75 from 617 votes.

Grey's Anatomy - S6E21

#11 - How Insensitive (Season 6 - Episode 21)

Bailey preps the team with mandatory sensitivity training prior to admitting a 700-pound patient with compounded medical issues, and the case proves to be challenging in every sense of the word. Meanwhile Derek has to come face to face with a former patient's husband in a wrongful death deposition, and spending time with a heart patient's daughter opens up some old wounds for Cristina.

The episode was rated 7.75 from 608 votes.

Grey's Anatomy - S6E5

#10 - Invasion (Season 6 - Episode 5)

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The residents of Seattle Grace and Mercy West vie for surgeries and their careers as day one of the hospital merger begins. Meanwhile, Arizona stands by an enraged Callie when her father, Mr. Torres, employs a priest to help convince her to date men, and Izzie experiences the brunt of her new surgical competition.

The episode was rated 7.76 from 638 votes.

Grey's Anatomy - S6E10

#9 - Holidaze (Season 6 - Episode 10)

As Thanksgiving, Christmas and New Year's pass, Miranda gets a visit from her father, William who disapproves of her choices in life. Mark and Lexie cope with an arrival of a woman from his past. Thatcher questions the Chief's recent behavior as Meredith comes to his defense.

The episode was rated 7.76 from 602 votes.

Grey's Anatomy - S6E14

#8 - Valentine's Day Massacre (Season 6 - Episode 14)

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It's Valentine's Day, and the doctors must treat dozens of injured people after the roof collapses at a popular romantic restaurant; Derek tries to manage his busy schedule as Chief of Surgery; Meredith wrestles with her new duties as the Chief's wife; and Mark and Callie team up to convince Sloan to do the right thing for her baby.

The episode was rated 7.78 from 603 votes.

Grey's Anatomy - S6E1

#7 - Good Mourning (Season 6 - Episode 1)

The hospital staff is left to deal with the aftermath of George's passing. Hitting the staff hard, they all find unique ways to get through the various stages of grief. George's mom returns, faced with the difficult task of deciding what to do with his organs.

The episode was rated 7.88 from 696 votes.

Grey's Anatomy - S6E15

#6 - The Time Warp (Season 6 - Episode 15)

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In his new role as Chief, Derek restores the hospital lecture series, and Richard, Bailey and Callie present to the group pivotal surgical cases from their pasts Bailey reflects on her first days as a shy resident, Callie looks back on a polio case, and Richard recalls a case in which he and Ellis worked on a patient diagnosed with GRID, a virus later called AIDS.

The episode was rated 7.94 from 637 votes.

Grey's Anatomy - S6E7

#5 - Give Peace a Chance (Season 6 - Episode 7)

When Isaac has an inoperable tumor wrapped around his spine, he wants Derek to do the impossible. Derek tests the Chief's authority when Richard objects to moving forward with the risky surgery.

The episode was rated 7.95 from 674 votes.

Grey's Anatomy - S6E8

#4 - Invest In Love (Season 6 - Episode 8)

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A generous 25 million donation is offered to Seattle Grace by the parents of Arizonas 10-year-old patient, she finds herself in a conflict of interest when his condition worsens. Cristina tests her boundaries with Owen at the hospital. Alex is left with all of Izzies hospital bills to contend with.

The episode was rated 7.98 from 643 votes.

Grey's Anatomy - S6E6

#3 - I Saw What I Saw (Season 6 - Episode 6)

After a burn victim unexpectedly dies in the midst of a chaotic ER, the Chief and board member Jennings interrogate the residents to find the culprit, as all the Mercy West and Seattle Grace resident defends their actions in an effort to save their jobs.

The episode was rated 7.98 from 639 votes.

Grey's Anatomy - S6E23

#2 - Sanctuary (Season 6 - Episode 23)

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In this heart-stopping episode of Grey's Anatomy titled "Sanctuary," Seattle Grace Hospital is thrown into a crisis like never before. Brace yourself for an intense rollercoaster ride of emotions as the hospital faces a purge that rivals even Game of Thrones' reputation for killing off characters. Shonda Rhimes, the mastermind behind the show, takes no prisoners in this devastating turn of events.

Fans of the show were left stunned and speechless after witnessing the unimaginable. Some even wished that the annoying intern, April, had met her untimely demise instead of the beloved character Reed. Emotions ran high as viewers expressed their shock and disbelief, questioning why poor Reed had to meet such a tragic end.

If you thought the previous season's tragedy was hard to bear, this episode takes it to a whole new level. It's an emotional gut-punch that will leave you reaching for the tissues. However, amidst all the chaos and despair, some characters manage to keep their composure while others are pushed to the brink. Watch as Reed's death, Alex's life-threatening situation, Derek's frantic state, and April's mental breakdown unfold alongside Meredith and Cristina's seemingly unaffected demeanor.

Grey's Anatomy never fails to deliver gripping and emotional storylines, and "Sanctuary" is no exception. Prepare yourself for an unforgettable episode that will have you on the edge of your seat and craving more.

The episode was rated 8.42 from 747 votes.

Grey's Anatomy - S6E24

#1 - Death and All His Friends (Season 6 - Episode 24)

In the gripping Grey's Anatomy episode, "Death and All His Friends," viewers are taken on an emotional rollercoaster as Cristina and Meredith face their toughest surgical challenge yet. The episode leaves no room for a break as these two strong-willed characters are pushed to their limits. Shonda Rhimes, the mastermind behind the show, delivers an epic and heart-wrenching season finale that will leave you breathless.

Fans were left reeling from the intensity of this episode. The comments flooded in, expressing the mix of emotions that viewers experienced. Some remarked that they didn't expect to feel so deeply, while others praised the episode as the most dramatic season finale yet. The devastating loss of George and the emotional aftermath had already shaken fans, but "Death and All His Friends" took it to a whole new level.

Prepare to have your heartstrings tugged as you witness the aftermath of this intense surgical challenge. The episode is a testament to the power of storytelling and the impact that a TV show can have on its audience. Brace yourself for an unforgettable viewing experience as Grey's Anatomy continues to captivate and move its dedicated fanbase.

The episode was rated 8.54 from 757 votes.

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