Cristina Yang has little sympathy for Constance Ferguson (special guest star Rosanna Arquette), a prison inmate who jeopardizes her health just to get out of solitary confinement. Meanwhile the interns all keep careful watch on the family of premature quintuplets with a variety of serious health challenges, Izzie's anger at Alex reaches boiling point, and Dr. Addison Shepherd decides to teach Izzie a very painful lesson.

The episode was rated 7.93 from 826 votes.

The holiday season has started but not everyone is in a festive mood. This is Alex's last day in the hospital unless he passes his boards practical exam the next day, thus everyone helps him to review so that he succeeds. However, Izzie is not happy about the others helping him and Meredith has to remind her of the true spirit of the Christmas holiday. Justin is in need of a new heart. One is available but he does not want it because he does not believe Santa gave it to him as his mother said. Cristina and Burke, both handling Justin's case, have opposing views on the matter due to their different stances on religion. Despite a reconciliation with his wife, Derek isn't in a festive mood. George has a simple case of a woman who has a bleeding ulcer, he realizes that the ulcer is caused by her entourage but fails to keep them away, with the consequence that it perforates.

The episode was rated 7.96 from 823 votes.

The staff attends to an intern from another hospital who has short-term memory loss. This intern, named Marshall, also has caused a car accident that involved a married couple, their unborn baby and the woman's parents who the staff are also treating. The pregnant woman is named Melanie and she will die but her baby may survive. One of the female interns meets up with a woman from her past who is planning on having a family of her own. Cristina is in a good mood although Alex, Izzie, George, and Meredith are having problems but in the meantime Burke hasn't forgiven Cristina for her late night faux pas. Meredith and Izzie are making fun of Callie's household habits and George and Callie are having a fight because of George's roommates. Addison is continuing to own Alex and he's upset about it. Denny has an outburst at Izzie and Derek has an outburst at Meredith.

The episode was rated 7.96 from 753 votes.

All the nurses at Seattle Grace Hospital go on strike, leaving the doctors to fend for themselves. George refuses to cross the picket line and finally joins the nurses on their strike while Alex, Cristina, Izzie and Meredith meets Bailey's stand-in: Dr. Cindy Aaron, the complete opposite of Miranda Bailey. Izzie agrees to work on a difficult pregnancy case with Addison, while Cristina and Alex are in the pit attending to a young married woman with a real bad case of rash. Meredith happens on an old woman that she needs to intubate and then learns she was DNR.

The episode was rated 7.97 from 788 votes.

Cristina, Izzie and Meredith take care of Shane, a man who appears to be crazy and claims that he is pregnant. Shane's case induces a spreading fascination among the staff. George relates to a patient's husband.

The episode was rated 8.00 from 870 votes.

Derek and Addison's relationship is rocked to the core when a former friend comes to Seattle Grace and his presence promises to shake things up for a few members of the staff. Burke and Cristina's relationship is affected when one of her secrets is outted. Alex and Izzie are having similar reactions to their closet scenes during the Code Black crisis. On top of this a cocky doctor shows up to piss Derek off in all kinds of ways. A patient is suffering from constant orgasms and her condition sparks interesting conversations among the staff. George is trying to figure out how to get Meredith to see him as more than just a housemate. Another patient, that Derek is treating, is dealing with a rare disorder and needs his parents support and understanding. Burke has a patient who inspires him to talk to Meredith and Cristina about doing what they say they will. Meanwhile, Meredith learns more about her family (in fact maybe more than she may have wanted to know) through her parents.

The episode was rated 8.01 from 796 votes.

As Cristina tries to recover, she proves to be a very difficult patient, and a visit from her mother doesn't improve her demeanor any. And Meredith's mother, Dr. Ellis Grey, has the hospital staff running in circles.

The episode was rated 8.01 from 898 votes.

Cristina goes right back to working right after being discharged. Izzie isn't talking to Alex. Derek and Meredith treat a patient. George and Alex get stuck in an elevator.

The episode was rated 8.06 from 903 votes.

Cristina and Meredith try to figure out if Cristina should tell Burke that she's pregnant right before Cristina faces an emergency. Alex and Izzie get closer while Meredith's mother gets too close.

The episode was rated 8.10 from 917 votes.

In the Grey's Anatomy episode "Into You Like a Train," the staff of Seattle Grace is faced with a chaotic situation as they receive victims from a devastating train wreck. The entire team is called in to handle the influx of patients, each with their own unique and challenging cases. However, amidst the chaos, two characters, Addison and Izzie, find themselves working closely with a pregnant woman, adding an emotional twist to the already intense atmosphere.

While the episode boasts an intriguing storyline, some fans were left questioning the credibility of certain medical scenarios. One viewer commented on the questionable decision to portray Kristina as a complete moron, raising concerns about the show's portrayal of medical professionals. Additionally, the idea of reattaching a leg that has been missing for hours was deemed by another viewer as an absurd and unrealistic concept. Despite these criticisms, Grey's Anatomy continues to captivate audiences with its dramatic and sometimes controversial medical cases.

On a different note, there have been ongoing discussions about the character Alex and the desire to see him removed from the show. Although the comment referred to him as an "asshole," it is clear that some viewers are not fond of his character and would like to see changes made. As the show progresses, it will be interesting to see how the writers address these concerns and shape the future of Grey's Anatomy.

The episode was rated 8.17 from 906 votes.

In this episode of Grey's Anatomy titled "17 Seconds," George and Derek find themselves working together, while Denny remains in need of a heart transplant. Meanwhile, Meredith is paired with Callie, leading to unexpected dynamics in the hospital. Tragedy strikes when a 12-week pregnant patient passes away during surgery, leaving her parents desperate to save the baby's life. This heartbreaking situation creates tension between Derek and Addison. As the episode unfolds, the actions of one doctor bring together two quarreling patients, highlighting the power of compassion amidst chaos. Additionally, Finn continues to provide medical care for Doc, his trusted furry companion.

The comments about this episode are quite polarizing. Some viewers express frustration with Izzie's actions, calling her "dumb" and one of the most annoying characters on television. Others criticize the overall professionalism of the characters, particularly Alex's behavior and the actions of the "psychopathic" women. It seems that the bomb episode was already difficult to digest for some viewers, and the ending of this episode has left them stunned.

Despite the mixed reactions, "17 Seconds" presents a compelling storyline filled with emotional moments and unexpected twists that will keep viewers hooked until the very end. It's another gripping installment of Grey's Anatomy that tackles both medical and personal challenges, leaving audiences eagerly anticipating what comes next.

The episode was rated 8.19 from 792 votes.

In this intense episode of Grey's Anatomy, titled "Deterioration of the Fight or Flight Response," the lives of several beloved characters hang in the balance. Denny, a patient in desperate need of a heart transplant, sends Izzie and George into a frenzy as they do everything they can to find a donor. Meanwhile, Derek faces a life-or-death situation as he operates on Burke, who was shot. However, due to Denny's deteriorating condition, Burke is unable to perform the heart transplant, leading to a dire situation. As if that wasn't enough, Cristina finds herself in charge of the ER, all while carrying the weight of her concern for Burke.

The emotional rollercoaster continues as fans weigh in on the events of this episode. Some viewers express frustration with Izzie's decision-making, criticizing her for letting her emotions cloud her judgment. Others share their heartbreak over the apparent end of the love story between Izzie and Denny, mourning the loss of a beloved character. However, there are also those who question the writing choices, calling for a better storyline and hoping for improvement in the next season. With so much at stake, the anticipation for what comes next in Grey's Anatomy is palpable.

The episode was rated 8.22 from 743 votes.

In the Grey's Anatomy episode "It's the End of the World," the tension at the hospital reaches a boiling point when an explosive case arrives in the operating room. This life-threatening situation forces Dr. Burke to declare a "Code Black," putting everyone's lives at risk. As the chaos unfolds, Bailey is faced with the worry of her husband's whereabouts while she is in labor. Meanwhile, sparks fly between Izzie and Alex, adding a layer of heat to an already intense situation.

This episode of Grey's Anatomy delivers a gripping storyline with actual medical cases, providing a refreshing break from the usual interpersonal drama. However, some viewers were left frustrated by Izzie's decision to once again get involved with Alex, leading to mixed reactions from fans. Despite this, the episode successfully keeps viewers on the edge of their seats, evoking a sense of stress and anticipation that Grey's Anatomy is known for. Brace yourself for an emotional rollercoaster as the hospital staff navigates through this life-and-death crisis in "It's the End of the World."

The episode was rated 8.47 from 910 votes.

In the Grey's Anatomy episode titled "As We Know It," the tension and emotions run high as the doctors of Seattle Grace Hospital face a crisis. Derek, still in the middle of an operation, discovers the troubling news about Meredith's current situation. Meanwhile, Meredith herself is freaking out, overwhelmed by the circumstances surrounding her. Webber and Bailey, dealing with their own medical health issues, find themselves in a challenging position. And Cristina and Izzie, affected by Meredith's situation, grapple with their own personal problems. As the hospital remains under code black, the situation only worsens, leaving everyone on edge.

This episode of Grey's Anatomy is nothing short of spectacular, delivering unforgettable drama and suspense. Viewers are left in shock, as unexpected events unfold, creating a terrifying and memorable experience. However, amidst all the chaos, it's worth noting that no main characters were harmed during the making of this episode. Some may wonder why the bomb squad members' fate wasn't given more attention, but the focus remains on the core characters and their personal struggles.

The ending of "As We Know It" is particularly poignant, leaving a lasting impact on the audience. While the bomb squad incident seemed to fade into the background, it's hard to ignore the sadness and shock that lingers. Additionally, the episode introduces a new complication in the form of a strained relationship between Izzie and Alex. The emotional rollercoaster continues as viewers root for Izzie to find someone who treats her better.

Overall, this episode of Grey's Anatomy pushes the boundaries of realism and captivates viewers with its intense storytelling. Brace yourself for a challenging and emotionally charged journey that will leave you reeling. Get ready for an episode that will make you say, "Ooff, that was a hard one!"

The episode was rated 8.48 from 873 votes.

In this intense episode of Grey's Anatomy, titled "Losing My Religion," the drama reaches its peak as secrets are revealed and emotions run high. Richard is determined to uncover the truth about a family member's condition and turns to Addison for answers. Meanwhile, Callie and George have a heart-to-heart conversation about their complicated feelings, adding a new layer of complexity to their relationship. And of course, Meredith and Derek have yet another conversation about their beloved dog, Doc. But will this talk finally bring them closer together or drive them further apart?

As with any Grey's Anatomy episode, the romantic relationships take center stage. However, some viewers have mixed feelings about the direction the show is taking. Many have grown tired of the predictable back-and-forth between Meredith and Derek, longing for a fresh perspective on their love story. And while the emotional impact of Denny and Izzie's relationship can't be denied, not everyone was a fan of their dynamic. The same goes for Burke and Christina, whose ongoing togetherness has left viewers wondering why they're still holding on. And let's not forget about Callie and George, whose desperate dynamic raises eyebrows.

Despite the mixed reviews, this episode manages to deliver some powerful moments. The departure of Izzie brings both sadness and relief, as viewers say goodbye to a character they may not have always liked. However, some fans question the realism of the storyline and the decisions made by the show's creators. The episode also leaves viewers on the edge of their seats, wondering what the consequences of Izzie's actions will be and how it will impact the future of the hospital. Love it or hate it, "Losing My Religion" is an episode that will keep you talking.

The episode was rated 8.55 from 717 votes.